Synthesis and prediction of toxicological and pharmacological properties of Schiff bases containing arylfuran and pyrazole moiety

Full paper
 
Natalia Kosylo(1), Andrii Hotynchan(1), Olha Skrypska(1) *, Yuriy Horak(2), Mykola Obushak(2)

(1) Department of Chemistry and Food Expertise, Yuriy Fedkovych Chernivtsi National University, Kotsyubynsky Str. 2, 58002 Chernivtsi, Ukraine

(2) Department of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodia Str. 6, 79005 Lviv, Ukraine

* Correspondence to: o.skrypska@chnu.edu.ua

Pages 62-73
 
 
Abstract

A series of new azomethines with pyrazole and arylfuran fragments – 4-[{(5-Arylfuran-2-yl)methylene}amino]-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one – are synthesized by the condensation of 4-aminoantipyrine and 5-arylfurfural using a Monowave 50 synthesis reactor. The structures of the obtained compounds are confirmed with 1H NMR and IR spectroscopy.

 

Keywords 
4-Aminoantipyrine, Aryl furan derivatives, Schiff bases, Probable pharmacological activity, Predicted toxicity
 
First published: 24.05.2024