Synthesis and prediction of toxicological and pharmacological properties of Schiff bases containing arylfuran and pyrazole moiety

 

 

¹ Department of Chemistry and Food Expertise, Yuriy Fedkovych Chernivtsi National University, Kotsyubynsky St. 2, 58002 Chernivtsi, Ukraine

² Department of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodia St. 6, 79005 Lviv, Ukraine

 

* Correspondence to: o.skrypska@chnu.edu.ua

 

pp. 62-73

 

 

A series of new azomethines with pyrazole and arylfuran fragments – 4-[{(5-Arylfuran-2-yl)methylene}amino]-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one – are synthesized by the condensation of 4-aminoantipyrine and 5-arylfurfural using a Monowave 50 synthesis reactor. The structures of the obtained compounds are confirmed with 1H NMR and IR spectroscopy.