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Home » A Useful Classification of Organic Reactions Based on the Flux of the Electron Density

A Useful Classification of Organic Reactions Based on the Flux of the Electron Density

2023 vol 2 issue 1

Review

Luis R. Domingo1, Mar Ríos-Gutiérrez1 *

1 Department of Organic Chemistry, University of Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia, Spain

Correspondence to: m.mar.rios@uv.es

Pages 1-24

https://doi.org/10.58332/scirad2023v2i1a01

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Abstract A useful classification of polar organic reactions in Forward Electron Density Flux (FEDF) and Reverse Electron Density Flux (REDF), based on the unambiguously analysis of the direction of the flux of the global electron density transfer (GEDT) at the transition state structures (TSs), has been recently proposed (RSC Adv. 2020, 10, 15394) within the Molecular Electron Density Theory. Further, non-polar reactions have been classified as Null Electron Density Flux (NEDF) (Eur. J. Org. Chem. 2020, 5938). This classification allows characterizing the nucleophilic/electrophilic species participating in polar reactions. Analysis of the electronic chemical potential m, and the electrophilicity w and nucleophilicity N indices, defined within Conceptual DFT, at the ground state (GS) of the reagents also permits to establish this classification of polar reactions.

Keywords polar reactions, global electron density transfer, electron density flux, molecular electron density theory

First published: 14.02.2023